Vanderbilt Studies Provide Key Positive Results for COVID Vaccine in Early-Stage Clinical Trial

An experimental coronavirus vaccine stimulated robust immune responses against SARS-CoV-2, the virus that causes COVID-19, and raised no serious safety concerns in an early-stage clinical trial.

The COVID vaccine, called mRNA-1273, was co-developed by Moderna Inc. in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Early findings from the Phase I clinical trial of the COVID vaccine, published this week in the New England Journal of Medicine, support further development of mRNA-1273. A large Phase III clinical trial is expected to begin this summer.

Vaccines and therapeutics are urgently needed to slow the unrelenting COVID-19 pandemic, which has sickened more than 13 million people worldwide and killed at least 572,746 as of July 14, 2020.

The Phase I trial of mRNA-1273 enrolled 45 healthy volunteers ages 18 to 55, who received two vaccinations 28 days apart. The interim report includes follow-up through day 57; participants will continue to be followed for one year after the second vaccination, with scheduled blood collections to characterize immune responses.

The Vanderbilt University Medical Center research team led by coronavirus expert Mark Denison, MD, Edward Claiborne Stahlman Professor of Pediatrics and director of the Division of Pediatric Infectious Diseases, is a key contributor to the Phase I trial testing. The researchers are analyzing the ability of antibodies in blood serum samples from trial participants to “neutralize” live SARS-CoV-2 and prevent the virus from infecting cultured cells.

“Our results show that the vaccine induces a robust neutralizing antibody response in healthy volunteers, which looks similar to responses in people who had COVID-19,” said Jim Chappell, MD, PhD, research associate professor of Pediatrics and director of the vaccine and antibody studies in the Denison laboratory. “This work, in conjunction with the results of other laboratory studies at the NIH and the favorable safety outcomes among vaccine recipients, supports advancement of mRNA-1273 into a large Phase III clinical trial.”

The Phase III trial will evaluate the effectiveness of mRNA-1273 for the prevention of COVID-19, compared to no COVID vaccine.

The mRNA-1273 vaccine uses genetic material (mRNA) encoding the SARS-COV-2 spike protein — the protein that protrudes crown-like from the virus surface, giving coronaviruses their name. The spike protein binds to receptors on human cells and enables virus entry. It is required for infection and is the target of many candidate SARS-CoV-2 vaccines.

The idea of the mRNA vaccine is for a person’s cells to use the mRNA instructions to produce spike protein and stimulate an immune response against it. Then, if the vaccinated person is exposed to SARS-CoV-2, their immune system should recognize and neutralize it to prevent infection.

If the mRNA vaccine technology is successful, it might become a routine way to quickly develop vaccines for any emerging viral threat.

The concept and design of the spike protein encoded in the Moderna vaccine was developed by Barney Graham, MD, PhD, a former Vanderbilt faculty member who is now deputy director of the NIAID Vaccine Research Center.

In addition to Denison and Chappell, team members participating in the studies of mRNA-1273 include Laura Stevens, MS, Andrea Pruijssers, PhD, Tia Hughes, MS, and Xiaotao Lu, MS. The studies at VUMC are supported by the NIH-funded Vanderbilt Vaccine and Treatment Evaluation Unit (VTEU) directed by Buddy Creech, MD, MPH (grant AI148684), the Vanderbilt Institute for Clinical and Translational Research directed by Gordon Bernard, MD (grant TR002243) and the Dolly Parton COVID-19 Research Fund.


National Margarita Day

A lot of us have really picked up an interest in tequila and it's no wonder. Its popularity is soaring in the U.S. and doesn't look like it'll be slowing down any time soon. The only contender would probably be whiskey. Meh, but they have their own day. Now, it's National Margarita Day and we put together some of the best margarita recipes around so you can pick one or maybe even all of them to try.

We have a few surprises in there too. Maybe it's not all about tequila but it certainly has a theme going on. Take a look at some of these great tequila brands and start making some amazing margaritas today!

Keep reading Show less
Photo by Scott Webb on Unsplash

Gender-Inclusive Universities and Student Privacy

For many students, attending university is a profound, often life-changing, transition. It is often the student’s first time living on their own without parental supervision. This lifestyle is also accompanied by a period of self-discovery, of defining and redefining a sense of personal identity largely independent of the influence of family and friends from home.

For students who are members of the LGBTQ+ community, this rite of passage can also be a deeply empowering one. Indeed, attending university may be the student’s first real opportunity to explore their gender identity in a safe, comfortable, and accepting college.

Keep reading Show less

José Cuervo's Reserva de la Familia agave fields

Disclaimer: My trip was provided courtesy of a press trip but all opinions about the trip and events are my own. Please note there are affiliate links and at no additional cost to you, I may earn a commission if you make a purchase.

I had the opportunity to visit Mexico for an event José Cuervo was putting on, the unveiling of their premium tequila brand, Reserva de la Familia. The trip was all about tequila, how to drink it properly, how to pair it with food, and of course, visiting various points of interest in Guadalajara while tasting tequila along the way.

Keep reading Show less